Endocrine Abstracts

Introduction: Markedly decreased plasma leptin concentrations in patients with lipodystrophy commonly lead to overeating. Leptin-replacement therapy improves feeding behavior in these patients. The aim of the present study is to clarify neural networks influenced by leptin signals for appetite regulation in the patients with lipodystrophy.Methods: We measured neural responses to visual food stimuli by use of functional magnetic resonance imaging (fMRI) a...